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KMID : 0381120200420070761
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Genes and Genomics
2020 Volume.42 No. 7 p.761 ~ p.771
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The role of CTNNB1 and LEF1 in feather follicles development of Anser cygnoides and Anser anser
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Sun Yue
Msuthwana Petunia
Liu Jing
Liu Chang
Sello Cornelius Tlotliso
Song Yupu
Feng Ziqiang
Li Shengyi
Yang Wei
Xu Yunpeng
Yan Xiaomin
Li Chuanghang
Sui Yujian
Hu Jingtao
Sun Yongfeng
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Abstract
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Background: Wingless-types/beta-catenin (Wnt/β-catenin) signaling pathway is one of the most extensively studied transcriptional cascades involved in various types of organogenesis including embryonic and postnatal development. Downy feather quantity is primarily affected by follicular development and gene regulations.
Objective: This research was aimed to investigate the role of catenin beta-1(CTNNB1) and lymphoid enhancerbinding factor-1 (LEF1) on feather follicles development at different developmental stages.
Methods: Fluorescence quantitative PCR, Western-blot and immunohistochemical methods were used in Anser cygnoides and Anser anser embryos (E12, E13 E18, and E28) and after birth gosling stages (G18, G48, G88) for gene expression analysis.
Results: CTNNB1 and LEF1 genes were expressed in Anser cygnoides and Anser anser at different embryonic and after-birth gosling developmental stages and the expression levels were significantly different in different stages (p?
Conclusion: Our study illustrated that CTNNB1 and LEF1 has an impact on Anser cygnoides and Anser anser feather follicles growth and development.
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KEYWORD
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Wnt, CTNNB1, LEF1, Anser cygnoides, Anser anser, Feather follicle development
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